Been in the LE/SWAT field for too many years and have observed projectiles of all different calibers with unpredictable results. Always vital, bullet placement such as center mass then follow thru with head shot is a standard training. Whomever moves the projectiles down range the quickest and accurately wins....training...muscle memory.
One of the most deadliest firearms encountered was a simple .22 nylon 66 semi auto with optics.
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